Document prepared by: SICS Data Management Platform
Document number: DM/CATALOGUE/002
Last reviewed: 19/02/2021
Data Access and Release Guidelines
Please view Data Access and Release Guidelines before using this catalogue.
Please view Form A for data request.
Please access Form B Application System (FAS) for abstract/manuscript submission.
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S-PRESTO Data Access and Release Guidelines
Singapore PREconception Study of long-Term maternal and child Outcomes (S-PRESTO) study is a collaborative research effort by KK Women's and Children's Hospital (KKH), National University of Singapore (NUS), National University Health System (NUHS) and A*STAR's Singapore Institute for Clinical Sciences (SICS). The S-PRESTO cohort study investigates pre-pregnancy influences on maternal and child health.
Over the course of 2015 and 2017, Singaporean women without fertility issues and intending to get pregnant were enrolled in S-PRESTO. With the longitudinal cohort study being in its 5th year, mother-child dyads have been extensively phenotyped with continuous collection of data. S-PRESTO has the advantage to prospectively assess a wide array of potential determinants of future health outcomes in women from preconception to post-delivery and in their offspring across the earliest development from embryonic stages into early childhood.
The S-PRESTO cohort provides a critical platform for replication of novel findings from GUSTO cohort study and discovery of new findings at preconception, where interventions could have the most significant impact. Researchers planning on research projects will have to adhere to the following procedures.
- Applicants can request datasets for their research projects by completing the Form A Project Proposal and submit it to Cohort Rep (Ann Huang). The project proposal requires a main applicant and S-PRESTO PI. Graduate students, post-doctoral fellows and other trainees must be supervised by a S-PRESTO PI.
- The Form A proposal will be reviewed by S-PRESTO Executive Committee (Exec):
- Sir Peter Gluckman/Prof Johan Eriksson
- Prof Chong Yap Seng
- Representatives from each Domain Cluster/Platform
- Other Executive Committee members
- Upon approval of Form A, Data Scientist (Png Hang) would initiate the data release process. If curated data is unavailable for an approved Form A, raw data would be provided for analysis if requested by applicant. The download link for analysis dataset would be shared with main applicant and S-PRESTO PI.
- If additional data variables are required during the course of research, the applicant may specify additional variables in Form A and submit it to Cohort Rep. If required, a new Form A may be requested to be submitted for approval.
- The applicant is responsible to ensure that Form A data is not distributed to anyone else not involved in project. No secondary analysis should be undertaken without written approval of the Exec.
- Applicant is responsible to ensure that the research publication/presentation is prepared within 12 months of Form A approval. The validity period of Form As can be extended further upon approval by the Exec.
- All public presentation of data (manuscripts/abstracts for poster & oral) containing any material derived from S-PRESTO datasets must be communicated to the Exec for approval. The Form B Public Presentation of Data should be submitted to Cohort Rep for approval workflows:
- Plagiarism check
- Submission of all data (with data dictionary) used in abstract/manuscript - archival of manuscript data folder
- Approval of abstract/manuscript and authorship by the Exec
- The applicant shall comply with all applicable laws, rules and regulations related to the use and distribution of data, including but not limited to the Singapore Personal Data Protection Act 2012 and the Singapore Human Biomedical Research Act 2015.
Demography/Others
| Theme | Topic | Curated by Data Team | Raw/In progress/Hardcopy |
|---|---|---|---|
| Maternal Demographics | Ethnicity | IE | None | Education, Work, Income | PCV1, PGV4 | M24*, YR4* | Housing, Household members | None | PCV1, PGV4, M24*, YR4* | Marital status, Religion | PCV1, PGV4 | M24*, YR4* |
| Paternal Demographics | Ethnicity | None | IE | Education, Work, Income | None | PRNV |
| COVID-19** | Parent COVID-19 Experiences Questionnaire | None | M12 |
Women's Health (Excluding Mental Health)
| Theme | Topic | Curated by Data Team | Raw/In progress/Hardcopy |
|---|---|---|---|
| Medical History | Family History of Diseases | PCV1 | YR4* | Reproductive/Obstetric History | PCV1, PGV1 | M24* | History of Diabetes Mellitus | IE | PGV4, PGV5, DEL, YR4* | History of Other Diseases/Conditions and Medications | IE | PCV1, PGV1, PGV3, PGV4, PGV5, M24*, YR4* |
| Personal Health & Lifestyle | Mother's Own Birth Outcomes and Place of Birth | PCV1 | None | Mother's Health (Running Nose, Blocked or Congested Nose, Fever, Rhinitis, Eczema, Asthma) | None | PCV1, PGV2, PGV3, PGV4, PGV5, M18* | Mother Allergy Assessment (Skin Prick) | None | M18*, M36* | Menstrual Cycles/Vaginal Bleeding | PCV1 | PGV2, PGV3, PGV5, M24*, YR4* | Monthly Menstrual Calendar | None | PCV1 | Personal Views of Breastfeeding | None | PGV4 | Smoking | PCV1, PGV1, PGV3, PGV5 | M24* | Alcohol | PCV1 | PGV1, PGV3, PGV5, M24*, YR4* | Female Sexual Function Index Questionnaire | PCV1 | None | Contraception | IE, PCV1 | M24*, YR4* | Pain Questionnaire | None | M3 | Physical Activity & Exercise | None | PCV1, PGV5, M12, M24* | Accelerometer | None | PCV1, PGV4 | Bowel Movement | PCV1, PGV1, PGV2, PGV3, PGV4, PGV5 | M24*, YR4* |
| Oral Health | Oral Health Questionnaire | None | PCV1, PGV4 | Orofacial Pain Questionnaire | None | PCV1, PGV4 | Xerostomia Self-Administered Questionnaire | None | PGV2 |
| Environment | Questionnaire (Expressways, Air-conditioning, Rooms, etc.) | None | PCV1, PGV5, M3, YR4* | Temperature and Humidity Measurement (Living Room, Bedroom) | None | PGV5, M3 | Light Exposure at Night | PGV1, PGV3, PGV5 | None | Exposure to Household/Environmental Pollutants | None | PCV1, M24*, YR4* |
| Pregnancy Test | Pregnancy Test | None | PCV1, PCV2, PGV1 | Last Menstrual Period | PCV1 | PCV2, PGV1 | Menstrual Phase | None | PCV1, PCV2 |
| Delivery Records | Details of Labour and Delivery | None | DEL | Delivery Annexes (Hypertension, Pre-eclampsia, Gestational Diabetes, IUGR, Multiple Pregnancies) | None | DEL | Pregnancy Complications and Medications | None | PGV3, PGV5, DEL | Oxytoxin Infusion Log | None | DEL |
| Breastfeeding | Breastfeeding Duration and Practices | PCV1, PGV1 | None |
Maternal Metabolic and Body Composition
| Theme | Topic | Curated by Data Team | Raw/In progress/Hardcopy |
|---|---|---|---|
| Anthropometric Measurements | Weight & Height Measurements | PCV1, PGV1, PGV2, PGV3, PGV4, PGV5 | M3, M6, M12, M24*, M36*, YR4* | Body Circumferences and Measurements | PCV1, PGV1, PGV2, PGV3, PGV4, PGV5 | M3, M6, M12, M24* | Skinfold Thicknesses | PCV1, PGV1, PGV2, PGV3, PGV4, PGV5 | M3, M6, M12, M24*, M36*, YR4* |
| Delivery Records | Gestational Data (Weight, Blood Pressure) | None | DEL | Laboratory Investigations, Vaginal Swabs | None | DEL |
| Body Composition | DXA | None | PCV1, M12 | BODPOD | PCV1 | M12, M24*, YR4* |
| Cardiovascular Assessment | Blood Pressure | PCV1, PGV1, PGV3, PGV5 | M3, M6, M12, M24*, M36*, YR4* | Basal Parameters | None | PCV1, PCV2, PGV4, M6 | Pulse Wave Analysis | None | PCV1, PCV2, PGV4, M6 | Functional Echo | None | PCV1, PCV2 | Carotid Intima-Media Thickness (CIMT) | None | PCV1 |
| Nutrition | Diet, Dieting, Health Supplements & Traditional Medicine | PCV1 | PGV1, PGV3, PGV4, PGV5, W3, M24*, YR4* | 3-Day Food Diary | None | PCV1 | Food Frequency Questionnaire (FFQ) | None | PCV1, PGV3, PGV5, W3, M24*, YR4* | Stunkard Three Factor Eating Questionnaire (TFEQ) | None | PCV2, PGV3, M24*, YR4* | Food Cravings and Aversions | None | PGV1 | Maternal Mealtimes | None | PGV1, PGV3, PGV5, M24* |
| Lab Investigations | Preconception Oral Glucose Tolerance Test | PCV1 | None | Antenatal Oral Glucose Tolerance Test | None | PGV4 | Postnatal Oral Glucose Tolerance Test | None | M3, M24*, M36*, YR4* | Full Blood Count | PCV1 | PGV2, PGV4, M3, M24*, M36*, YR4* | HbA1c | PCV1 | PGV2, PGV4, M3, M24*, M36*, YR4* | Bone Panel | None | PCV1 |
Maternal Sleep, Personality and Mental Health
| Theme | Topic | Curated by Data Team | Raw/In progress/Hardcopy |
|---|---|---|---|
| Sleep | PSQI (Pittsburgh Sleep Quality Index) | None | NDV1-PCV, PGV1, NDV2-PGV, PGV5, M6, M12, M36*, YR4* | Epworth Sleepiness Scale | None | NDV1-PCV, PGV1, NDV2-PGV, PGV5, M6, M12 | Morningness-Eveningness Questionnaire | None | NDV1-PCV, PGV1, PGV5 |
| Personality | Big Five Inventory | None | NDV1-PCV | Interpersonal Orientation Scale/Measure | None | NDV1-PCV, PGV1, NDV2-PGV, PGV5, M6 | Interpersonal Reactivity Index Questionnaire | None | M6, M12 |
| Psychological State | STAI (State Trait Anxiety Inventory) | None | NDV1-PCV, PGV1, NDV2-PGV, PGV5, M3, M6, M36*, YR4* | EPDS (Edinburgh Postnatal Depression Scale) | None | NDV1-PCV, PGV1, NDV2-PGV, PGV5, M3, M6 | Beck Depression Inventory-II | None | NDV1-PCV, PGV1, NDV2-PGV, PGV5, M3, M6, M36*, YR4* | Structured Clinical Interview for DSM Disorders (SCID) | None | NDV1-PCV | Perceived Stress Scale | None | NDV1-PCV, PGV1, NDV2-PGV, PGV5, M6 | Childhood Trauma Questionnaire | None | NDV1-PCV | Emotional Processing Task | None | NDV1-PCV, NDV2-PGV | Adult Attachment Interview (AAI) | None | NDV2-PGV | Parental Bonding Instrument (PBI) | None | NDV1-PCV, NDV2-PGV | Life Experiences Survey | None | NDV1-PCV, M6 | Mother electroencephalogram task/ERP | None | M6 | Pregnancy Anxiety Questionnaire | None | PGV1, NDV2-PGV, PGV5 | Pregnancy Experiences Scale | None | PGV1, NDV2-PGV, PGV5 | Generalized Self-Efficacy | PCV1 | PGV4 | General Health Questionnaire | None | NDV1-PCV |
| Belief and Attitude | Body Image Questionnaire | None | NDV1-PCV, PGV1, NDV2-PGV, PGV5, M6 | Experiences in Close Relationships (ECR) | None | M6 | Sensitivity to Reward | None | NDV1-PCV, PGV1, NDV2-PGV, PGV5 | Multidimensional Scale of Perceived Social Support | None | NDV1-PCV, PGV1, NDV2-PGV, PGV5, M6 | Sufficiency of Practical/ Emotional Support | None | NDV1-PCV, PGV1, NDV2-PGV, PGV5, M6 | Other Sources of Social Support | None | NDV1-PCV, PGV1, NDV2-PGV, PGV5, M6 | Need to Belong | None | NDV1-PCV, PGV1, NDV2-PGV, PGV5, M6 | Sociodemographic Questionnaire | None | NDV1-PCV, PGV1, NDV2-PGV, PGV5 | Belief in a Dangerous World | None | NDV1-PCV, M6 |
| Cognition | Parental Cognition about Sleep | None | M6, M12 |
| Excecutive Functioning | Cambridge Neuropsychological Test Automated Battery (CANTAB) - Spatial Working Memory | None | NDV1-PCV, NDV2-PGV | Dimensional Change Card Sort (DCCS) | None | NDV1-PCV, NDV2-PGV, M3 | Flanker Task | None | NDV1-PCV, NDV2-PGV, M3 |
| Parenting | Daily Hassles and Uplifts & Parenting H&U | None | M6 | The Parental Interactive Bedtime Behaviour Scale (PIBBS) | None | M6, M12 |
| Micelleanous | Edinburgh Handedness Inventory | None | NDV1-PCV | Relational Binding Task | None | NDV1-PCV, NDV2-PGV, M3 | Parent's Experience in Loss Questionnaire | None | NDV2-PGV, M6, M12 | Shipley-II | None | NDV1-PCV, NDV2-PGV |
Children's Health (Excluding Neurodevelopment)
| Theme | Topic | Curated by Data Team | Raw/In progress/Hardcopy |
|---|---|---|---|
| Delivery Records | Infant Data | None | DEL | NICU CRF | None | DEL | Neonatal Problems | None | DEL |
| General Health and Allergy | Child's Health (Running Nose, Blocked or Congested Nose, Fever, Rhinitis, Eczema, Asthma) | None | W3, W6, M3, M6, M12, M18*, M24*, M36*, YR4* | Eczema Examination | None | M3, M12 | Functional Gastrointestinal Disorders systems & the Infant Gastroesophageal Reflux Questionnaire (I-GERQ-R) | None | W6, M3, M6, M12 | Hospitalization/Surgery/Medication | None | W1, W6, M3, M6, M12, M18*, M24*, M36*, YR4* | SCORAD | None | M6, M18*, M36* | Child Allergy Assessment (Skin Prick) | None | M6, M18*, M36* |
| Physical Activity | Outdoor/Indoor Pre-school activities | None | M24*, M36*, YR4* | Child 7-day Activities Watch Diary | None | YR4* |
| Environment | Questionnaire (Childcare Attendance, Expressways, Air-conditioning, Rooms, etc.) | None | M3, YR4* | Temperature and Humidity Measurement (Living Room, Bedroom) | None | M3 | Exposure to Household/Environmental Pollutants | None | M24*, YR4* |
Child Metabolic and Body Composition
| Theme | Topic | Curated by Data Team | Raw/In progress/Hardcopy |
|---|---|---|---|
| Anthropometric Measurements | Infant Daily Weight Measurements | None | DEL | Weight & Height Measurements | None | DEL, W1, W3, W6, M3, M6, M12, M18*, M24*, M36*, YR4* | Body Circumferences and Measurements | None | DEL, W1, W3, W6, M3, M6, M12, M18*, M24*, YR4* | Skinfold Thicknesses | None | DEL, W1, W3, W6, M3, M6, M12, M18*, M24*, M36*, YR4* | Anogenital Measurements | None | DEL, M3, M12 |
| Body Composition | PEAPOD | None | DEL, W1, M3 | QMR | None | M3, M6, M12, M18*, M24*, M36*, YR4* |
| Cardiovascular Assessment | Blood Pressure | None | M36*, YR4* |
| Weaning, Diet and Eating Behavior | Infant and Child's 3-day Food Diary | None | M6, M12 | Baby and Child Eating Behaviour Questionnaire (BEBQ)/(CEBQ) | None | M3, M18*, M36* | Maternal Feeding Practices and Beliefs for Children and Toddlers (MFPBC/MFPBT) | None | M18* | Child Feeding Practices (Including Child Weaning), Dietary Supplements and Probiotics | None | W1, W3, W6, M3, M6, M12, M18*, M24* | Weaning Food List | None | M6, M12 | Child's Feeding (Food List) | None | M18* |
| Lab Investigations | Heel Prick Test | None | DEL |
Child Neurodevelopment
| Theme | Topic | Curated by Data Team | Raw/In progress/Hardcopy |
|---|---|---|---|
| Behaviour, emotion and relationship | Child Behavioural Checklist (CBCL) | None | M36*, YR4* | Strange Situation | None | M12 |
| Disorders Assessment | Family Interview for Genetics Study (FIGS) (by Mother) | None | M3 | Family Interview for Genetics Study (FIGS) (by Father) | None | M6 |
| Memory | Child Memory Task | None | M6 |
| Parenting | Father-child behavioural observation | None | M6 | Mother-child behavioural observation | None | M6 | Primary Caregiver Questionnaire (PCQ) and Retrospective Language (by Mother) | None | M6, M12 | Primary Caregiver Questionnaire (PCQ) and Retrospective Language (by Father) | None | M6 |
| Sleep | Brief Infant Sleep Questionnaire (BISQ) (by Mother) | None | M6, M12, M36* | Brief Infant Sleep Questionnaire (BISQ) (by Father) | None | M6 |
| Miscelleneous | Parental Expectations for Child's Social Development (by Mother) | None | M6, M12 | Parental Expectations for Child's Social Development (by Father) | None | M6 |
Life Events & Social Relationships
| Theme | Topic | Curated by Data Team | Raw/In progress/Hardcopy |
|---|---|---|---|
| Infant and Child Care | Child Care Arrangements | PCV1 | PGV4, M24*, YR4* |
Paternal Factors
| Theme | Topic | Curated by Data Team | Raw/In progress/Hardcopy |
|---|---|---|---|
| Health | Medical Conditions (Diabetes, Hypertension) | None | PRNV | Blood Pressure | None | PRNV | Anthropometric Measurements | None | PRNV | Father's Own Birth Outcomes and Place of Birth | None | PRNV |
| Lifestyle | Smoking | None | PRNV | Alcohol Consumption | None | PRNV | Physical Activity | None | PRNV |
| General | General Health Questionnaire | None | PRNV | Food Frequency Questionnaire (FFQ) | None | PRNV |
| Paternal Sleep, Personality and Mental Health | Generalised Self-Efficacy | None | PRNV | PSQI (Pittsburgh Sleep Quality Index) | None | M6 | Beck Depression Inventory-II | None | M6 | Perceived Stress Scale | None | M6 | Life Experiences Survey | None | M6 | Multidimensional Scale of Perceived Social Support | None | M6 | Sufficiency of Practical/ Emotional Support | None | M6 | Other Sources of Social Support | None | M6 | Need to Belong | None | M6 | Belief in a Dangerous World | None | M6 | Interpersonal Orientation Scale | None | M6 | Cambridge Neuropsychological Test Automated Battery (CANTAB) - Spatial Working Memory | None | NDV1-PCV, M6 | Parent's Experience of Loss | None | M6 | Parental Cognition about Sleep | None | M6 | The Parental Interactive Bedtime Behaviour Scale (PIBBS) | None | M6 | Daily Hassles and Uplifts & Parenting H&U | None | M6 |
Imaging
| Theme | Topic | Curated by Data Team | Raw/In progress/Hardcopy |
|---|---|---|---|
| Pregnancy Ultrasound | Dating | None | PGV1, PGV2 | Ultrasound Observations | None | PGV1, PGV2, PGV3, PGV4, PGV5 | Ultrasound Measurements | None | PGV2, PGV3, PGV4, PGV5 | Assessment of Uterine Artery Doppler | None | PGV3 | Blood Flow: Umbilical artery | None | PGV4, PGV5 | Blood Flow: Middle Cerebral Artery | None | PGV4, PGV5 | Blood Flow: Umbilical Vein | None | PGV4, PGV5 | Blood Flow: Uterine Artery | None | PGV4, PGV5 |
| Maternal Adiposity by MRI | Abdominal Fat | None | PCV1, M3 | Brown Fat | None | PCV1, M3 | Liver | None | PCV1, M3 | Muscle Fat | None | PCV1, M3 |
| Maternal Neuroimaging | Brain MRI | None | PCV1, M3 |
| Maternal Retinal Imaging | Fundus Images (Retinal Microvasculature) | None | PCV2, PGV2, PGV4, PGV5 |
| Child Adiposity by MRI | Abdominal Fat | None | W1, M3, M9 | Brown Fat | None | W1, M3, M9 | Liver | None | W1, M3, M9 | Muscle Fat | None | W1, M3, M9 |
| Child Neuroimaging | Brain MRI | None | W1, M3, M9 |
Omics (Mother)
| Theme | Topic | Curated by Data Team | Raw/In progress/Hardcopy |
|---|---|---|---|
| Biochemical Metabolic and Inflammatory Markers | Analysis of Hair Cortisol Hormone | None | NDV1-PCV, PGV1, NDV2-PGV, PGV5, M6 |
| Nutritional Phenotyping | Micronutrient Analyses of Maternal Blood Samples for Bevital Panels B, C, D and H | None | PCV1, PGV4, M3 |
| Blood Plasma Markers (Hormones & Adipocytokines) | Analysis of Blood Markers Related to Maternal Metabolic Health | None | PCV1, PGV4, M3 |
* visits for the timepoint still ongoing
** COVID-19 Questionnaire was done within a 2-month period, thus subjects are in varying timepoints.
*** work in progress and may require longer processing time
Some of these datasets are only available for a subset of the cohort
| IE | Inclusion/Exclusion |
| PCV | Preconception Visit |
| NDV1-PCV | Neurodevelopment-Preconception Visit |
| PGV | Pregnancy Visit |
| NDV2-PGV | Neurodevelopment-Pregnancy Visit |
| DEL | Delivery Visit |
| PRNV | Partner Visit |
| WK | Postnatal Week |
| M | Postnatal Month |
| YR | Postnatal Year |
S-PRESTO Data Catalogue will be released quarterly with new updates and changes. Data Management Platform is continuously working on ensuring the accuracy and completeness of the catalogue.